3 years ago

KLB, encoding β-Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism

KLB, encoding β-Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism
Richard Quinton, William F Crowley, Valérie Schwitzgebel, Yisrael Sidis, Trevor R Cole, Hichem Miraoui, Andrew A Toogood, Emmanuel Somm, Moosa Mohammadi, Daniele Cassatella, Nicolas J Niederländer, Nelly Pitteloud, Urs Albrecht, Andrew A Dwyer, Vincent Prevot, Gerasimos P Sykiotis, Lacey Plummer, James Acierno, Andrea Messina, Cheng Xu, Jeremy MW Kirk, Christian De Geyter, Justine Bouilly, Mirjam Dirlewanger, Manuel Tena-Sempere, Tarja Kinnunen
Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic form of isolated gonadotropin-releasing hormone (GnRH) deficiency caused by mutations in > 30 genes. Fibroblast growth factor receptor 1 (FGFR1) is the most frequently mutated gene in CHH and is implicated in GnRH neuron development and maintenance. We note that a CHH FGFR1 mutation (p.L342S) decreases signaling of the metabolic regulator FGF21 by impairing the association of FGFR1 with β-Klotho (KLB), the obligate co-receptor for FGF21. We thus hypothesized that the metabolic FGF21/KLB/FGFR1 pathway is involved in CHH. Genetic screening of 334 CHH patients identified seven heterozygous loss-of-function KLB mutations in 13 patients (4%). Most patients with KLB mutations (9/13) exhibited metabolic defects. In mice, lack of Klb led to delayed puberty, altered estrous cyclicity, and subfertility due to a hypothalamic defect associated with inability of GnRH neurons to release GnRH in response to FGF21. Peripheral FGF21 administration could indeed reach GnRH neurons through circumventricular organs in the hypothalamus. We conclude that FGF21/KLB/FGFR1 signaling plays an essential role in GnRH biology, potentially linking metabolism with reproduction. Defects in FGF21/KLB/FGFR1 signaling contribute to GnRH deficiency in both humans and mice. This signaling pathway is a novel link between metabolism and reproduction.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.15252/emmm.201607376

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