3 years ago

Early-Life Gut Dysbiosis: A Driver of Later-Life Fibrosis?

John Varga, Karen J Ho
Using a novel mouse model of scleroderma induced by immunization with topoisomerase-I peptide-loaded dendritic cells, Mehta et al. found that early-life antibiotic exposure resulted in increased later-life fibrosis in the skin and lungs. These observations advance the novel concept that gut microbiome alterations caused by early-life exposures may contribute to scleroderma pathogenesis, and warrant in-depth characterization and validation in complementary disease models.

Publisher URL: http://doi.org/10.1016/j.jid.2017.08.017

DOI: 10.1016/j.jid.2017.08.017

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