Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Cobalt(II)-Catalyzed Isocyanide Insertion Reaction with Sulfonyl Azides in Alcohols: Synthesis of Sulfonyl Isoureas

Cobalt(II)-Catalyzed Isocyanide Insertion Reaction with Sulfonyl Azides in Alcohols: Synthesis of Sulfonyl Isoureas
Tian Jiang, Ling Yin, Zheng-Yang Gu, Shun-Yi Wang, Shun-Jun Ji
A Co(II)-catalyzed isocyanide insertion reaction with sulfonyl azides in alcohols to form sulfonyl isoureas via nitrene intermediate has been developed. This protocol provides a new, environmentally friendly, and simple strategy for the synthesis of sulfonyl isourea derivatives by employing a range of substrates under mild conditions.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01127

DOI: 10.1021/acs.joc.7b01127

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