3 years ago

Portable Optical Resolution Photoacoustic Microscopy (pORPAM) for Volumetric Imaging of Multiscale Organisms

Lei Xi, Tian Jin, Huabei Jiang, Huikai Xie, Heng Guo, Lei Yao
Photoacoustic microscopy (PAM) provides a fundamentally new tool for a broad range of studies of biological structures and functions. However, the use of PAM has been largely limited to small vertebrates due to the large size/weight and inconvenience of the equipment. Here, we describe a portable optical resolution photoacoustic microscopy (pORPAM) system for three-dimensional (3D) imaging of small-to-large rodents and humans with a high spatiotemporal resolution and a large field of view (FOV). We show extensive applications of pORPAM to multiscale animals including mice and rabbits. In addition, we image the 3D vascular networks of human lips, and demonstrate the feasibility of pORPAM to observe the recovery process of oral ulcer and cancer-associated capillary loops in human oral cavities. This technology is promising for broad biomedical studies from fundamental biology to clinical diseases.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/jbio.201700250

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