Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Matsutakone and Matsutoic Acid, Two (Nor)steroids with Unusual Skeletons from the Edible Mushroom Tricholoma matsutake

Matsutakone and Matsutoic Acid, Two (Nor)steroids with Unusual Skeletons from the Edible Mushroom Tricholoma matsutake
Tao Feng, Zheng-Hui Li, Ji-Kai Liu, Ling Zhang, Bin Wu, He-Ping Chen, Zhen-Zhu Zhao
Matsutakone (1), a novel sterol with an unprecedented polycyclic ring system, together with a new norsteroid matsutoic acid (2) were isolated from the fruiting bodies of Tricholoma matsutake. Their structures and absolute configurations were assigned by extensive spectroscopic analyses and computational methods. Bioassay results showed that compounds 1 and 2 exhibited inhibitory activities against acetylcholinesterase (IC50 20.9 μM for 1).

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01230

DOI: 10.1021/acs.joc.7b01230

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