3 years ago

Synergistic Manganese(I) C−H Activation Catalysis in Continuous Flow: Chemoselective Hydroarylation

Synergistic Manganese(I) C−H Activation Catalysis in Continuous Flow: Chemoselective Hydroarylation
Svenja Warratz, Lutz Ackermann, Fabio Pesciaioli, Hui Wang, João C. A. Oliveira
Chemoselective hydroarylations were accomplished by a novel synergistic Brønsted acid/manganese(I)-catalyzed C−H activation manifold. Thus, alkynes bearing O-leaving groups could, for the first time, be employed for C−H alkenylations without concurrent β-O elimination, thereby setting the stage for versatile late-stage diversifications. Also described is the first manganese-catalyzed C−H activation in continuous flow, thus enabling efficient hydroarylations within only 20 minutes. Mn with the flow: Synergistic Brønsted acid/manganese(I) catalysis enables chemoselective hydroarylations, in flow, within 1 to 20 minutes, and sets the stage for versatile late-stage modifications. The reaction features facile C−H cleavage and the use of nontoxic sustainable manganese.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201708271

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.