3 years ago

Scopranones with Two Atypical Scooplike Moieties Produced by Streptomyces sp. BYK-11038

Scopranones with Two Atypical Scooplike Moieties Produced by Streptomyces sp. BYK-11038
Nozomu Watanabe, Ryuji Uchida, Takenobu Katagiri, Satoshi Ohte, Hiroshi Tomoda, Ayumu Demachi, Ibuki Suwa, Masaki Ohtawa, Tohru Nagamitsu, Daiki Lee
Three new compounds, designated scopranones A–C, were isolated from the culture broth of a soil isolate, Streptomyces sp. BYK-11038, and shown to be inhibitors of bone morphogenetic protein (BMP) induced alkaline phosphatase activity in a BMP receptor mutant cell line. The structures were elucidated using NMR and other spectral data. The scopranones have an unusual structure with two atypical scooplike moieties linked at the tails to form part of a unique 3-furanone ring.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b03003

DOI: 10.1021/acs.orglett.7b03003

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