Accounts of Chemical Research
Accounts of Chemical Research
5 years ago

Using Cooperatively Folded Peptides To Measure Interaction Energies and Conformational Propensities

Using Cooperatively Folded Peptides To Measure Interaction Energies and Conformational Propensities
Jeffery W. Kelly, Maziar S. Ardejani, Evan T. Powers
The rates and equilibria of the folding of biopolymers are determined by the conformational preferences of the subunits that make up the sequence of the biopolymer and by the interactions that are formed in the folded state in aqueous solution. Because of the centrality of these processes to life, quantifying conformational propensities and interaction strengths is vitally important to understanding biology. In this Account, we describe our use of peptide model systems that fold cooperatively yet are small enough to be chemically synthesized to measure such quantities.

Publisher URL: http://dx.doi.org/10.1021/acs.accounts.7b00195

DOI: 10.1021/acs.accounts.7b00195

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