3 years ago

Segmentation Genes Enter an Excited State

Segmentation Genes Enter an Excited State
Ryoichiro Kageyama, Hiroshi Kori, Akihiro Isomura

The expression of segmentation clock genes is self-oscillatory due to a delayed negative-feedback mechanism. Hubaud et al. (2017), reporting in Cell, now reveal that segmentation clock genes also exhibit properties of an excitable system, with Yap signaling setting the threshold for adopting an oscillatory state and Notch signaling triggering oscillations.

Publisher URL: http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30821-3

DOI: 10.1016/j.devcel.2017.10.008

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