3 years ago

Oral tobramycin prophylaxis prior to colorectal surgery is not associated with systemic uptake.

M F Q Kluytmans-van den Bergh, R M P H Crolla, J A J W Kluytmans, T Mulder, J Romme, A A M Ermens, N E van 't Veer
Preoperative oral prophylaxis with non-absorbable antibiotics has been reported to reduce the risk of surgical site infections after colorectal surgery. This prospective study was conducted to evaluate the risk of toxic side effects by measuring postoperative serum tobramycin levels in patients who received a three-day prophylaxis with tobramycin and colistin prior to colorectal surgery. In all patients, serum tobramycin concentrations were below the detection limit (0.3 mg/L), implying a low risk of toxicity.

Publisher URL: http://doi.org/10.1128/AAC.01723-17

DOI: 10.1128/AAC.01723-17

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