3 years ago

Antimicrobial Activity of Aztreonam-Avibactam and Comparator Agents Tested against Contemporary (2016) Clinical Enterobacteriaceae Isolates.

Robert K Flamm, Rodrigo E Mendes, Mariana Castanheira, Helio S Sader, Michael A Pfaller, Dee Shortridge
A total of 10,451 contemporary (2016) Enterobacteriaceae isolates from 84 United States (U.S.) medical centers and 116 metallo-β-lactamases and/or OXA-48-like producing Enterobacteriaceae from other countries were tested against aztreonam-avibactam and comparators. All U.S. isolates were inhibited at aztreonam-avibactam MIC of ≤8 μg/mL (MIC50/90, ≤0.03/0.12 μg/mL), including KPC-producing (n=102; MIC50/90, 0.25/0.5 μg/mL), multidrug-resistant (n=876; MIC50/90, 0.06/0.25 μg/mL), and extensively drug-resistant (n=111; MIC50/90, 0.12/0.5 μg/mL) isolates. The highest aztreonam-avibactam MIC value among ex-U.S. isolates was 4 μg/mL.

Publisher URL: http://doi.org/10.1128/AAC.01856-17

DOI: 10.1128/AAC.01856-17

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