3 years ago

Direct C2-Functionalization of Indoles Triggered by the Generation of Iminium Species from Indole and Sulfonium Salt

Direct C2-Functionalization of Indoles Triggered by the Generation of Iminium Species from Indole and Sulfonium Salt
Kazuya Nomura, Koki Kawachi, Tomomi Kawasaki, Nozomi Saito, Kazuhiro Higuchi, Masanori Tayu
An indole core bearing a functional group on the C2 position is often found as a key structure in biologically active natural products and pharmaceuticals. Here, we report direct C2-functionalization of indoles triggered by the formation of an iminium species generated from indole and a sulfonium reagent. The reaction proceeded under very mild conditions to give the corresponding C2-substituted indole derivatives in good to high yields. Pulling the trigger: Direct C2-functionalization of indoles triggered by the formation of an iminium species generated from indole and a sulfonium salt is demonstrated. The reaction proceeded under very mild conditions to give the C2-substituted indole derivatives in good to high yields.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201702338

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