3 years ago

Suppression of Long non-coding RNA LET potentiates Bone Marrow-derived Mesenchymal Stem Cells (BMSCs) proliferation by up-regulating TGF-β1

Xin Jin, Zhihong Fan, Zhiliang Zhang, Yi Lu
Long non coding RNAs (lncRNAs) show an encouraging trend in regulating the proliferation of bone marrow-derived mesenchymal stromal cells (BMSCs). The present study investigated the role of lncRNA low expression in tumor (LET) in BMSCs proliferation. Our result showed that LET was down-regulated in rapidly proliferated BMSCs (P < 0.05). Suppression of LET promoted BMSCs proliferation and over-expression of LET inhibited BMSCs proliferation (P < 0.05). LET negatively regulated the expression of transforming growth factor β1 (TGF-β1) in BMSCs (P < 0.05). Knockdown of TGF-β1 reversed the LET suppression-induced BMSCs proliferation (P < 0.05). Moreover, knockdown of TGF-β1 alleviated the LET suppression-induced activation of Wnt/β-catenin pathway in BMSCs. Therefore, we drew the conclusion that LET suppression promoted BMSCs proliferation by up-regulating the expression of TGF-β1 and activating Wnt/β-catenin pathway. This article is protected by copyright. All rights reserved

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/jcb.26459

You might also like
Never Miss Important Research

Researcher is an app designed by academics, for academics. Create a personalised feed in two minutes.
Choose from over 15,000 academics journals covering ten research areas then let Researcher deliver you papers tailored to your interests each day.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.