3 years ago

Oligosaccharide Sensing in Aqueous Media by Porphyrin–Curdlan Conjugates: A Prêt-á-Porter Rather Than Haute-Couture Approach

Oligosaccharide Sensing in Aqueous Media by Porphyrin–Curdlan Conjugates: A Prêt-á-Porter Rather Than Haute-Couture Approach
Munenori Numata, Yoshihisa Inoue, Tadashi Mori, Gaku Fukuhara, Mayuko Sasaki
Porphyrin–curdlan conjugates selectively bound tetrasaccharide acarbose, a drug for type-2 diabetes, from mono- to hexasaccharides. The spectral range employed (>400 nm), high selectivity for acarbose, low detection limit (0.2 mm), and broad dynamic range (0.2–45 mm) make these sensors attractive for use in diabetes research, diagnosis, and therapy. Hence, the present prêt-á-porter approach, rather than haute-couture one, combining a hydrogen-bonding saccharide co-aggregate component (curdlan) with a signal-readout reporter (porphyrin) should be expandable to other sensing systems which are thought to be difficult to operate in aqueous media. More information can be found in the Full Paper by G. Fukuhara, Y. Inoue et al. (DOI: 10.1002/chem.201701360).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201702834

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