3 years ago

Back Cover: Total Syntheses of Lepadiformine Marine Alkaloids with Enantiodivergency, Utilizing Hg(OTf)2-Catalyzed Cycloisomerization Reaction and their Cytotoxic Activities (Chem. Eur. J. 40/2017)

Back Cover: Total Syntheses of Lepadiformine Marine Alkaloids with Enantiodivergency, Utilizing Hg(OTf)2-Catalyzed Cycloisomerization Reaction and their Cytotoxic Activities (Chem. Eur. J. 40/2017)
Yoshiki Morimoto, Haruka Nokubo, Takeshi Kodama, Tomoyuki Koyama, Kengo Yamauchi, Momochika Kumagai, Kunihiro Matsumura, Shinnosuke Ezaki, Keisuke Nishikawa, Seiho Kikuchi
A phenomenon of enantiodivergence was found in lepadiformine marine alkaloids isolated from a single species marine tunicate Clavelina moluccensis. The enantioselective total syntheses have been achieved by key mercury(II) triflate-catalyzed cycloisomerization reaction from a functionalized linear substrate to a 1-azaspiro[4.5]decane compound, and cytotoxic activities of synthesized lepadiformines and their synthetic intermediates were also evaluated. More information can be found in the Full Paper by Y. Morimoto et al. on page 9535.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201702291

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