3 years ago

Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens

Wenyan Lu, Bini Mathew, Judith V. Hobrath, Robert C. Reynolds, Yonghe Li

Abstract

As part of an ongoing program to study the anticancer activity of non-steroidal anti-inflammatory drugs (NSAIDs) through generating diversity libraries of multiple NSAID scaffolds, we synthesized a series of NSAID amide derivatives and screened these sets against three cancer cell lines (prostate, colon and breast) and Wnt/β-catenin signaling. The evaluated amide analog libraries show significant anticancer activity/cell proliferation inhibition, and specific members of the sets show inhibition of Wnt/β-catenin signaling.

Publisher URL: https://link.springer.com/article/10.1007/s00044-017-2001-z

DOI: 10.1007/s00044-017-2001-z

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