3 years ago

Click Chemistry: Novel Applications in Cell Biology and Drug Discovery

Click Chemistry: Novel Applications in Cell Biology and Drug Discovery
Stefan A. Laufer, Matthias Gehringer
A safe BET: Apart from target engagement, subcellular location and tissue distribution are critical parameters in drug discovery. A novel, generalizable approach has been reported that involves exploiting click chemistry to elucidate these parameters. By using clickable analogues of known Bromodomain and extraterminal domain (BET) inhibitors, various labels were introduced in situ and utilized to determine the biological fate of these probes.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201710195

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