3 years ago

Nickel/Photoredox-Catalyzed Amidation via Alkylsilicates and Isocyanates

Nickel/Photoredox-Catalyzed Amidation via Alkylsilicates and Isocyanates
David N. Primer, Shuai Zheng, Gary A. Molander
A nickel/photoredox, dual-catalyzed amidation reaction between alkylsilicate reagents and alkyl/aryl isocyanates is reported. In contrast to the previously reported reductive coupling process, this protocol is characterized by mild reaction conditions and the absence of a stoichiometric reductant. A mechanistic hypothesis involving a nickel-isocyanate adduct is proposed based on literature precedent and further validation by experimental results.

Publisher URL: http://dx.doi.org/10.1021/acscatal.7b02795

DOI: 10.1021/acscatal.7b02795

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