3 years ago

A Highly Active Manganese Catalyst for Enantioselective Ketone and Ester Hydrogenation

A Highly Active Manganese Catalyst for Enantioselective Ketone and Ester Hydrogenation
Gavin J. Harkness, Magnus B. Widegren, Alexandra M. Z. Slawin, David B. Cordes, Matthew L. Clarke
A new hydrogenation catalyst based on a manganese complex of a chiral P,N,N ligand has been found to be especially active for the hydrogenation of esters down to 0.1 mol % catalyst loading, and gives up to 97 % ee in the hydrogenation of pro-chiral deactivated ketones at 30–50 °C. Non-precious metal for valuable catalysis: A new manganese catalyst for enantioselective ketone hydrogenation has been developed (see scheme). This catalyst also hydrogenates esters at low catalyst loadings for an earth-abundant metal system.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201702406

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