3 years ago

Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity

Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity
Xin-Hua Liu, Hui-Jie Cheng, Wei-Wei Ge, Qing-Shan Li, Hua-Jian Xu, Ban-Feng Ruan

Abstract

Twenty-three novel resveratrol-based cinnamic ester hybrids were designed and synthesized. All the compounds were evaluated for their anti-inflammatory activity using RAW264.7 cells. Among them, compound D15 was found to be the most potent one in inhibiting NO production in LPS-stimulated RAW264.7 cells. The further study indicated that compound D15 could suppress expression of proteins iNOS, COX-2, p-p65, and p-IκB LPS-induced. Immunofluorescence further revealed compound D15 could reduce activation p65 in nuclei. All the results indicated that the anti-inflammatory activity of title compound may partly due to its inhibitory effect on the NF-κB signaling pathway.

Publisher URL: http://www.tandfonline.com/doi/full/10.1080/14756366.2017.1381090

DOI: 10.1080/14756366.2017.1381090

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