4 years ago

Antibacterial Narrow Band Gap Conjugated Oligoelectrolytes with High Photothermal Conversion Efficiency

Ming Wang, Martin Seifrid, Guangxue Feng, Guillermo Carlos Bazan, Liu Bin, Bing Wang
Two conjugated oligoelectrolytes (COEs), abbreviated as WMG1 and WMG2, were designed and synthesized with the goal of achieving near infrared absorption and high photothermal conversion efficiency. Specifically, electron rich thiophene and electron-poor benzo[1,2-c:4,5-c']bis([1,2,5]thiadiazole subunits were introduced in the conjugated core to modulate the optical gap and to reduce the fluorescence emission efficiency. WMG1 and WMG2 show absorption maxima around 800 nm, which is located in the NIR window and thereby favors tissue penetration. Although relatively small in terms of molecular dimensions, WMG1 and WMG2 exhibit photothermal conversion efficiencies of ~ 60 % and 53%, respectively. WMG1 shows dark toxicity to the gram positive bacterium B. subtilis and good photothermal killing efficiency toward both B. subtilis and Gram negative E. coli, features that demonstrate the promising potential of the COE molecular design for photothermal applications.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201709887

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