3 years ago

Hughes and Gleason's Virosaine A—Appreciating the Art in Synthesis

Hughes and Gleason's Virosaine A—Appreciating the Art in Synthesis
Bryan D. Ellis, Christopher D. Vanderwal
The synthesis of the Securinega alkaloid virosaine A by Hughes and Gleason is a perfect example of the intersection of art and chemical synthesis. An ingenious cascade reaction builds most of the polycyclic architecture, but necessitates a challenging C−H functionalization, which is ultimately accomplished by an unusual directed lithiation reaction.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201708051

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