3 years ago

Asymmetric α-Allylation of α-Substituted β-Ketoesters with Allyl Alcohols

Asymmetric α-Allylation of α-Substituted β-Ketoesters with Allyl Alcohols
Masanori Yoshida
Enantioselective α-allylation of α-substituted β-ketoesters with simple allyl alcohols was successfully performed by synergistic catalysis with the catalyst combination of a chiral primary amino acid and an achiral palladium complex without additional promotors like acids or bases. The allylation reaction and generation of a chiral quaternary carbon stereocenter proceeded smoothly to produce α,α-disubstituted β-ketoesters in high yields (91–99%) with high enantioselectivities (90–99% ee).

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b02188

DOI: 10.1021/acs.joc.7b02188

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