3 years ago

Biocompatible palm stearin-based polyesteramide as polymer carrier for solid dispersion

Biocompatible palm stearin-based polyesteramide as polymer carrier for solid dispersion
Shew Fung Wong, Choy Sin Lee, Wei Seng Wong, Wen Huei Lim, Hui Meng Er
Palm stearin-based polyesteramide (PSPEA) was synthesized by reacting PS with diethanolamine, followed by azelaic acid at functionality molar ratio (OH: COOH) ranged 1:0.84 to 1:0.95 at 150–190 °C. FTIR, 1H-nuclear magnetic resonance, 13C-nuclear magnetic resonance, and gel permeation chromatography were used to elucidate the chemical structure and Mw distribution of the PSPEA. PSPEA 4000 (acid value = 0.61 mg KOH/g sample, hydroxyl value = 51.97 mg KOH/g sample) was used in combination with stearic acid-based PEA to prepare mefenamic acid (MA) solid dispersion. The solid dispersion demonstrated sixfold and twofold enhancement in T50% and cumulative drug release as compared to pure MA. The differential scanning calorimetry and scanning electron microscopy analyses revealed solubilization of MA in PEA and transformation of MA into amorphous. In vitro cytotoxicity studies confirmed the safety profile of PSPEA against 3T3 fibroblast cell lines. This work demonstrated that the biocompatible PSPEA possesses surface tension lowering and anticrystallization effects have the potential as polymer carrier for pharmaceutical dosage forms. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 135, 45892.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/app.45892

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.