5 years ago

Cu-Catalyzed Aminodifluoroalkylation of Alkynes and α-Bromodifluoroacetamides

Cu-Catalyzed Aminodifluoroalkylation of Alkynes and α-Bromodifluoroacetamides
Qian Zhang, Qingqing Wang, Qian Chen, Jiejie Niu, Weiya Pu, Yunhe Lv
The copper-catalyzed highly regioselective aminodifluoroalkylation of alkynes and α-bromodifluoroacetamides was realized for the first time. With this method, 3,3-difluoro-1H-pyrrol-2(3H)-ones were constructed in a single step from various alkynes and α-bromodifluoroacetamides substrates without using any extra oxidant.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01313

DOI: 10.1021/acs.joc.7b01313

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