Organic Letters
Organic Letters
5 years ago

Phosphine-Catalyzed Enantioselective [4 + 2] Annulation of o-Quinone Methides with Allene Ketones

Phosphine-Catalyzed Enantioselective [4 + 2] Annulation of o-Quinone Methides with Allene Ketones
Weijun Yao, Tianli Wang, Zhen Wang, Yixin Lu
A phosphine-catalyzed highly enantioselective [4 + 2] annulation between ortho-quinone methides and allene ketones has been developed. The reported method led to the formation of chromane derivatives in high yields and excellent enantioselectivity. This is the first time that ortho-quinone methides are employed in phosphine-mediated cyclization reactions.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01936

DOI: 10.1021/acs.orglett.7b01936

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