3 years ago

Type I IFN receptor signalling controls IL-7-dependent accumulation and activity of protumoral IL-17A-producing γδT cells in breast cancer.

David Dombrowicz, Christophe Paget, Sébastien Fleury, Maya Hassane, Emmanuel C Patin, François Trottein, Christelle Faveeuw, Daphnée Soulard
The protumoral activity of γδT17 cells has recently emerged in a wide variety of solid malignancies including breast cancer. These cells promote tumor growth, angiogenesis, and subsequent metastasis development. However, the factors that regulate the biology of γδT17 cells within the tumor microenvironment are poorly understood. Here we use two experimental models of breast cancer to reinforce the concept that tumor-infiltrating γδT17 cells are endowed with protumoral functions that promote tumor progression and metastasis development. We also demonstrated a critical role for type I interferon signaling in controlling the preferential accumulation of a peculiar subset of γδT17 cells displaying a CD27- CD3bright phenotype in the tumor bed, previously associated with the invariant Vγ6Vδ1+ TCR. This effect was indirect and relied partially on IFNAR1-dependent control of IL-7 secretion, a factor that triggers proliferation and activating functions of deleterious γδT17 cells. Our work identifies a key role of the type I interferon/IL-7 axis in the regulation of intratumoral γδT17 cell functions and in the development of primary breast tumor growth and metastasis.

Publisher URL: http://doi.org/10.1158/0008-5472.CAN-17-1416

DOI: 10.1158/0008-5472.CAN-17-1416

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.