5 years ago

Iridium-Catalyzed Direct Regioselective C4-Amidation of Indoles under Mild Conditions

Iridium-Catalyzed Direct Regioselective C4-Amidation of Indoles under Mild Conditions
Jingsong You, Jiangliang Yin, Boya Feng, Xuesong Zheng, Shiping Yang, Shuyou Chen
An efficient Ir-catalyzed amidation of indoles with sulfonyl azides is disclosed, affording diverse C4-amidated indoles exclusively under mild conditions. In this protocol, a variety of indoles with commonly occurring functional groups such as formyl, acetyl, carboxyl, amide, and ester at the C3 position are well tolerated.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b00730

DOI: 10.1021/acs.orglett.7b00730

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