Organic Letters
Organic Letters
5 years ago

Visible-Light Photoredox Difluoromethylation of Phenols and Thiophenols with Commercially Available Difluorobromoacetic Acid

Visible-Light Photoredox Difluoromethylation of Phenols and Thiophenols with Commercially Available Difluorobromoacetic Acid
Yunhe Jin, Min Jiang, Haijun Yang, Jinyan Yang, Hua Fu
A simple and efficient visible-light photoredox one-pot method for difluoromethylation of phenols and thiophenols has been developed. The protocol uses commercially available, inexpensive, and easy handling difluorobromoacetic acid as the difluoromethylating agent, and the diverse O- and S-difluoromethylated products were prepared in good yields with tolerance of many functional groups.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01118

DOI: 10.1021/acs.orglett.7b01118

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