3 years ago

Epigenetics in the Eye: An Overview of the Most Relevant Ocular Diseases.

Hanan A Alkozi, Rafael Franco, Jesús J Pintor
Sight for mammals is one of the most appreciated senses. In humans there are several factors that contribute to the increment in all kind of eye diseases. This mini-review will focus on some diseases whose prevalence is steadily increasing year after year for non-genetic reasons, namely cataracts, dry eye, and glaucoma. Aging, diet, inflammation, drugs, oxidative stress, seasonal and circadian style-of-live changes are impacting on disease prevalence by epigenetics factors, defined as stable heritable traits that are not explained by changes in DNA sequence. The mini-review will concisely show the data showing epigenetics marks in these diseases and on how knowledge on the epigenetic alterations may guide therapeutic approaches to have a healthy eye.

Publisher URL: http://doi.org/10.3389/fgene.2017.00144

DOI: 10.3389/fgene.2017.00144

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