3 years ago

Virus Infection and Death Receptor-Mediated Apoptosis.

Xingchen Zhou, Xiaozhen Liang, Zhongshun Liu, Wenbo Jiang, Shuai Liu
Virus infection can trigger extrinsic apoptosis. Cell-surface death receptors of the tumor necrosis factor family mediate this process. They either assist persistent viral infection or elicit the elimination of infected cells by the host. Death receptor-mediated apoptosis plays an important role in viral pathogenesis and the host antiviral response. Many viruses have acquired the capability to subvert death receptor-mediated apoptosis and evade the host immune response, mainly by virally encoded gene products that suppress death receptor-mediated apoptosis. In this review, we summarize the current information on virus infection and death receptor-mediated apoptosis, particularly focusing on the viral proteins that modulate death receptor-mediated apoptosis.

Publisher URL: http://doi.org/10.3390/v9110316

DOI: 10.3390/v9110316

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