3 years ago

Synthesis and biological evaluation of a D-ring-contracted analogue of lamellarin D

Synthesis and biological evaluation of a D-ring-contracted analogue of lamellarin D
A D-ring contracted analogue of the strongly cytotoxic marine pyrrole alkaloid lamellarin D was synthesized and investigated for its antiproliferative action towards a wild type and a multidrug resistant (MDR) cancer cell line. The compound was found to inhibit tumor cell growth at submicromolar concentrations and showed a lower relative resistance in the MDR cell line than the antitumor drug camptothecin to which lamellarin D shows cross resistance and with which lamellarin D shares the same binding site.

Publisher URL: www.sciencedirect.com/science

DOI: S0968089616311099

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