3 years ago

Peptides and their Metal Complexes in Neurodegenerative Diseases: from Structural Studies to Nanomedicine Prospects.

Diego La Mendola, Cristina Satriano, Giuseppe Trapani
Metal ions dyshomeostasis is increasingly recognized to play a crucial role in the development of aging-related neurodegenerative diseases. Metal trafficking in the brain is related to the proteins that regulate the uptake and efflux of metals in neurons. Different pathways may occur depending on specific binding features of metallo-protein complexes, such as conformational changes, redox processes and aggregates formation. Specifically, copper, zinc and iron are recognized to influence the biochemistry of proteins involved in neurodegeneration, including A, prions, -synuclein and, among others, neurotrophins, crucial in neuronal development and efficiency. Nowadays the application of peptide-based drugs is widespread for different pathologies, but the short lifetime in vivo due to proteolysis and other shortcomings still limit their use. To this respect, both ad hoc peptide synthesis and nanomaterials/nanotools offer a multifarious scenario of action. Recently, new peptides inspired by natural metallo-peptides or metalloproteins have been synthesized in order to mimic the metal binding activities of protein involved in neurons survival. Moreover, peptide-based nanostructures, e.g., self-assembling peptides, have been demonstrated as promising biomaterials in tissue engineering for blood vessels, and other tissues, or as substrates for neurite outgrowth and synapse formation. In this paper, the recent developments on metal-binding peptides and peptide nanostructures for therapeutic application in neurodegenerative diseases is reviewed, with a specific focus on the metal ion interaction effects in both structural and biological properties of neurotrophin-like peptides.

Publisher URL: http://doi.org/10.2174/0929867324666171026163144

DOI: 10.2174/0929867324666171026163144

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.