3 years ago

Hainanmycin A, a cyclo-heptadeca macrolide bearing a cyclopentenone moiety from the mangrove-derived Streptomyces sp. 219807

Hainanmycin A, a cyclo-heptadeca macrolide bearing a cyclopentenone moiety from the mangrove-derived Streptomyces sp. 219807
A macrocyclic polyketide with novel carbon skeleton, namely hainanmycin A, was isolated from the mangrove-derived Streptomyces sp. 219807. This polycyclic compound featured a cyclo-heptadeca framework possessing a 5,6-disubstituted-4-hydroxy-2-pyrone moiety in conjunction with a 2-cyclopentenone residue. The structure was established by spectroscopic analyses, and the stereochemistry was determined by NMR chemical shifts calculations and time-dependent density functional theory (TDDFT) calculation of electronic circulardichroism (ECD). A possible biogenetic pathway for hainanmycin A was proposed.

Publisher URL: www.sciencedirect.com/science

DOI: S0040403917312510

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