Organic Letters
Organic Letters
5 years ago

Palladium-Catalyzed C–H Trifluoroethoxylation of N-Sulfonylbenzamides

Palladium-Catalyzed C–H Trifluoroethoxylation of N-Sulfonylbenzamides
Yongzheng Ding, Zhihua Cai, Gang Li, Shangda Li, Lei Fu, Long Yang, Lei Cai, Huafang Ji
The trifluoroethyl aryl ethers are important motifs in drug molecules. However, a report devoted specifically to the study of transition-metal-catalyzed C–H trifluoroethoxylation has not been reported to date. A protocol of Pd(II)-catalyzed o-C–H trifluoroethoxylation of a broad range of benzoic acid derivatives (i.e., N-sulfonylbenzamides) has been developed. This method is also applied to the formal synthesis of the drug molecule flecainide, wherein the first m-C–H trifluoroethoxylation is also exemplified.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01103

DOI: 10.1021/acs.orglett.7b01103

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.