5 years ago

Palladium-Catalyzed C–H Trifluoroethoxylation of N-Sulfonylbenzamides

Palladium-Catalyzed C–H Trifluoroethoxylation of N-Sulfonylbenzamides
Yongzheng Ding, Zhihua Cai, Gang Li, Shangda Li, Lei Fu, Long Yang, Lei Cai, Huafang Ji
The trifluoroethyl aryl ethers are important motifs in drug molecules. However, a report devoted specifically to the study of transition-metal-catalyzed C–H trifluoroethoxylation has not been reported to date. A protocol of Pd(II)-catalyzed o-C–H trifluoroethoxylation of a broad range of benzoic acid derivatives (i.e., N-sulfonylbenzamides) has been developed. This method is also applied to the formal synthesis of the drug molecule flecainide, wherein the first m-C–H trifluoroethoxylation is also exemplified.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01103

DOI: 10.1021/acs.orglett.7b01103

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