International Journal of Biological Macromolecules
International Journal of Biological Macromolecules
5 years ago

Tough chitosan hydrogel based on purified regeneration and alkaline solvent as biomaterials for tissue engineering applications

Tough chitosan hydrogel based on purified regeneration and alkaline solvent as biomaterials for tissue engineering applications
The chitosan based on purified regeneration could be dissolved in 6wt% aqueous NaOH without freeze-thawing cycles and acetylation processing, and such a solution system was effective and different from other dissolving methods Upon heating, a tough hydrogel was constructed from the chitosan (purified regeneration) alkaline solution. The results of XRD, TEM, SEM and rheology analysis proved that chitosan easily aggregated in the solution and formed a nanofibers network to gelate at elevated temperature and concentration. The merely chitosan hydrogel had a uniform network structure and its (5wt%) compressive fracture stress could reach 0.2MPa. Furthermore, the hydrogels exhibited excellent biodegradability, blood compatibility and cellular compatibility. Therefore, the tough chitosan hydrogels may have a wide range of applications in biomedicine.

Publisher URL: www.sciencedirect.com/science

DOI: S0141813016327647

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