3 years ago

Long-term follow-up of the Incidence of Helicobacter pylori

Helicobacter pylori (H. pylori) causes peptic ulcer disease and gastric cancer. Understanding the incidence of H. pylori could help guide research on potential infection prevention strategies. Previous studies indicate infection occurs in young children, but the risk of infection in older children and adolescents is unclear. Our hypothesis was that H. pylori infection is rare in adolescence or adulthood. Our aim was to determine the incidence of H. pylori over a prolonged follow-up in a cohort of 626 non-infected individuals. Methods Participants, including index children, mothers, fathers and siblings, from a previous study (1997-2002) were traced, and 883/946 participated in this extended follow-up. We used the 13C-urea breath test (13C-UBT) to determine the incidence of H. pylori among 626 family members not infected in 2002, including 75 younger siblings, not born or too young for testing in 2002. Results 8/210 (3.8%) index participants (mean age 17.92 SD 0.77 years) became infected during 11.07 SD 0.56 years of follow-up (incidence: 3.42/1000 person-years 95%CI:1.48-6.74). Only 1/165 older siblings (0.6%) became infected (incidence:0.57/1000 person-years; 95%CI:0.007-3.16), and 1/176 parents became infected (incidence:0.63/1000 person-years 95%CI:0.01-3.5). Of 75 younger siblings (mean age 10.9 SD2.85 years) who were too young or not born in 2002, 9 (12%) became infected (incidence:11.32/1000 person-years, 95%CI:5.27-21.49). The highest incidence of H. pylori infection was in those born after 2005. Conclusion The incidence of H. pylori is extremely low in older children and adults in developed countries. Spontaneous clearance of infection is uncommon in our study population.

Publisher URL: www.sciencedirect.com/science

DOI: S1198743X17305827

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