Organic Letters
Organic Letters
5 years ago

Amide Directed Cross-Coupling between Alkenes and Alkynes: A Regio- and Stereoselective Approach to Substituted (2Z,4Z)-Dienamides

Amide Directed Cross-Coupling between Alkenes and Alkynes: A Regio- and Stereoselective Approach to Substituted (2Z,4Z)-Dienamides
Guofu Zhong, Feifei Li, Ke Zhang, Keke Meng, Jian Zhang, Zhenwei Lin
A ruthenium-catalyzed direct cross-coupling between alkenes and alkynes via directed C–H bond activation is described. By using N,N-disubstituted aminocarbonyl as a directing group, this oxidant-free and atom-economic protocol resulted in high efficiency and good stereoselectivities, which opens a novel synthetic passway for access to substituted (Z,Z)-butadiene skeletons.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b00695

DOI: 10.1021/acs.orglett.7b00695

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