3 years ago![Synthesis of Furo[2,3-c]pyridazines via Tandem Transition-Metal Catalysis](/image/eyJ1cmkiOiJodHRwOi8vc3RhY2thZGVtaWMuaGVyb2t1YXBwLmNvbS9pbWFnZT9pbWFnZV9pZD00MzU5NCIsImZvcm1hdCI6IndlYnAiLCJxdWFsaXR5IjoxMDAsIndpZHRoIjo1MTIsIm5vQ2FjaGUiOnRydWV9.webp)
Synthesis of Furo[2,3-c]pyridazines via Tandem Transition-Metal Catalysis
David L. Waller, Jacob M. Ganley
A general and efficient catalytic approach to synthesis of the furo[2,3-c]pyridazine ring system is reported. Building on the easily accessible 2-bromo-3-aminopyridizinone skeleton, a tandem Sonogashira coupling–cycloisomerization provides ready access to functionalized furopyridazines. A wide functional group tolerance was observed in the tandem reaction, which proceeds in high yield in 1–3 h. The structure of the heterocyclic ring system was confirmed through single-crystal X-ray crystallography.
Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01819
DOI: 10.1021/acs.joc.7b01819
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