4 years ago

Synthesis of Furo[2,3-c]pyridazines via Tandem Transition-Metal Catalysis

Synthesis of Furo[2,3-c]pyridazines via Tandem Transition-Metal Catalysis
David L. Waller, Jacob M. Ganley
A general and efficient catalytic approach to synthesis of the furo[2,3-c]pyridazine ring system is reported. Building on the easily accessible 2-bromo-3-aminopyridizinone skeleton, a tandem Sonogashira coupling–cycloisomerization provides ready access to functionalized furopyridazines. A wide functional group tolerance was observed in the tandem reaction, which proceeds in high yield in 1–3 h. The structure of the heterocyclic ring system was confirmed through single-crystal X-ray crystallography.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01819

DOI: 10.1021/acs.joc.7b01819

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