3 years ago

A biologically inspired two-species exclusion model: effects of RNA polymerase motor traffic on simultaneous DNA replication.

Andreas Schadschneider, Bhavya Mishra, Soumendu Ghosh, Shubhadeep Patra, Debashish Chowdhury

We introduce an ASEP-like model to describe the effects of RNA polymerase (RNAP) traffic on DNA replication. It contains two particle species representing RNAP and replication forks (replisomes), respectively, that can interact leading e.g. to the detachment of RNAPs. An interesting aspect is that the RNAP motion is performed on a lattice that is effectively decreasing in length. Using Monte Carlo simulation and an heuristic analytical approach based on exact results for the ASEP we make predictions for the RNAP traffic that might be tested in future experiments.

Publisher URL: http://arxiv.org/abs/1710.11582

DOI: arXiv:1710.11582v1

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