3 years ago

Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne

Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne
Christoph Rader, Chin-Yuan Chang, Nan Wang, Jian-Jun Chen, Dong Yang, Ben Shen, Ajeeth Adhikari, Ivana Crnovcic, Xiaohui Yan
A new anthraquinone-fused enediyne, yangpumicin A (YPM A, 1), along with four Bergman cyclization congeners (YPM B–E, 25), was isolated from Micromonospora yangpuensis DSM 45577 after mining enediyne biosynthetic gene clusters from public actinobacterial genome databases and prioritizing the hits by an enediyne genome neighborhood network analysis for discovery. YPM A is potent against a broad spectrum of human cancer cell lines. The discovery of 1 provides new opportunities for the functionalization of enediynes to develop new conjugation chemistries for antibody–drug conjugates.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b03120

DOI: 10.1021/acs.orglett.7b03120

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