3 years ago

In Situ Metastable Form: A Route for the Generation of Hydrate and Anhydrous Forms of Ceritinib

In Situ Metastable Form: A Route for the Generation of Hydrate and Anhydrous Forms of Ceritinib
Peddy Vishweshwar, Saladi Venkata Narasayya, Sudarshan Mahapatra, Ramanaiah Chennuru, Ravi Teja Koya, Pavan Kommavarapu, R. Ravi Chandra Babu, Prakash Muthudoss
Two novel forms of ceritinib are identified during the course of polymorph screening. The scientific rationale behind this discovery is clearly nailed down by the integration of experimental and theoretical approaches. The anhydrous and hydrate forms of ceritinib are isolated by following pH modulation crystallization. Both the polymorphs have advantages in terms of stability, solubility, and dissolution rate compared to Form 1. The present discovery has demonstrated a new approach of crystallization with scientific rationale.

Publisher URL: http://dx.doi.org/10.1021/acs.cgd.7b01027

DOI: 10.1021/acs.cgd.7b01027

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