3 years ago

Homo- and Heterobinuclear Cu2+ and Zn2+ Complexes of Ditopic Aza Scorpiand Ligands as Superoxide Dismutase Mimics

Homo- and Heterobinuclear Cu2+ and Zn2+ Complexes of Ditopic Aza Scorpiand Ligands as Superoxide Dismutase Mimics
Begoña Verdejo, Javier Pitarch-Jarque, Enrique García-España, Antonio García-España, Lluís Guijarro, Sandra Trefler, Antonio Doménech-Carbó, Javier U. Chicote, Mario Inclán
The synthesis, acid−base behavior, and Cu2+, Zn2+, and Cu2+/Zn2+ coordination chemistry of two new azamacrocyclic ligands have been studied by potentiometry, cyclic voltammetry, and UV−vis spectroscopy. The stoichiometry of the predominant mixed complex formed in solution at pH 7, [CuZnL]4+, agrees with that obtained for the crystalline compound [CuZnL2Cl2](ClO4)2·1.64H2O. The homodinuclear Cu complexes of these ligands show the highest protective capacity in a SOD1-deficient yeast model.

Publisher URL: http://dx.doi.org/10.1021/acs.inorgchem.7b01756

DOI: 10.1021/acs.inorgchem.7b01756

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