3 years ago

A new variant of 16S rRNA methylase, RmtD3, in a clinical isolate of Pseudomonas aeruginosa in Myanmar.

San Mya, Tatsuya Tada, Teruo Kirikae, Htay Htay Tin, Khin Nyein Zan, Kyoko Kuwahara, Kayo Shimada
A new variant of a 16S rRNA methylase, RmtD3, was detected in a clinical isolate of Pseudomonas aeruginosa in Myanmar. RmtD3 had 9 amino acid substitutions, such as Trp26Cys, Val39Ala, Met66Leu, Ser102Ile, Thr130Ala, Asn165Asp, Leu169Met, Ala181Thr and Gly236Ser, compared with RmtD. The RmtD3-producing P. aeruginosa was highly resistant to the aminoglycosides that were tested. The genomic environment surrounding rmtD3 was tnp (IS91 family)-orfA-orfB-mraW-rmtD3-orfC-orfD-yraL-tnp (IS91 family) on the chromosome.

Publisher URL: http://doi.org/10.1128/AAC.01806-17

DOI: 10.1128/AAC.01806-17

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