4 years ago

Mutations at the ribosomal S10 gene in clinical strains of Staphylococcus aureus with reduced susceptibility to tigecycline.

A Deplano, C Nonhoff, O Denis, M Dodémont, M Angeles Argudín, S Roisin
Mutations on the tip of the extended loop of ribosomal S10 protein have been associated with tigecycline (TGC) resistance in passaged mutants of different bacteria species. This study described the first two clinical TGC-resistant Staphylococcus aureus isolates with these mutations. One strain (TGC-MIC=2 mg/L) had a 12-nucleotide deletion affecting residues 56 to 59 (HKYK) of the S10 protein. The second strain (TGC-MIC=1 mg/L) had amino-acid substitutions (K57M, Y58F) previously described in S. aureus passaged mutants.

Publisher URL: http://doi.org/10.1128/AAC.01852-17

DOI: 10.1128/AAC.01852-17

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.