3 years ago

A Novel Method for Chronic Social Defeat Stress in Female Mice

Raisa Alam, Piray Atsak, René Hen, Joshua A Gordon, Scott S Bolkan, Emma S Holt, E David Leonardo, Alexander Z Harris, Atheir I Abbas, Zachary H Bretton, Mitchell P Morton
Top

Abstract

Historically, preclinical stress studies have often omitted female subjects, despite evidence that women have higher rates of anxiety and depression. In rodents, many stress susceptibility and resilience studies have focused on males since one commonly used paradigm—chronic social defeat stress—has proven challenging to implement in females. We report a new version of the social defeat paradigm that works in female mice. By applying male odorants to females in order to increase resident male aggressive behavior, we find that female mice undergo repeated social defeat stress and develop social avoidance, decreased sucrose preference and decreased time in the open arms of the elevated plus maze relative to control mice. Moreover, a subset of the female mice in this paradigm display resilience, maintaining control levels of social exploration and sucrose preference. This method produces comparable results to those obtained in male mice and will greatly facilitate studying female stress susceptibility.

Publisher URL: https://www.nature.com/articles/npp2017259

DOI: 10.1038/npp.2017.259

You might also like
Never Miss Important Research

Researcher is an app designed by academics, for academics. Create a personalised feed in two minutes.
Choose from over 15,000 academics journals covering ten research areas then let Researcher deliver you papers tailored to your interests each day.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.