3 years ago

The effects of periconceptional maternal alcohol intake and a postnatal high-fat diet on obesity and liver disease in male and female rat offspring.

Jacinta I Kalisch-Smith, Suyinn Chong, Leigh C Ward, Stephen T Anderson, James S M Cuffe, Mary E Wlodek, Emily S Dorey, Lisa Yamada, Marie Pantaleon, Sarah Steane, Helle Bielefeldt-Ohmann, Emelie M Gardebjer, Karen M Moritz
The effects of maternal alcohol consumption around the time of conception on offspring are largely unknown and difficult to determine in a human population. This study utilized a rodent model to examine if periconceptional alcohol (PC:EtOH), alone or in combination with a postnatal high-fat diet (HFD) resulted in obesity and liver dysfunction. Sprague-Dawley rats were fed a control or ethanol-containing liquid diet (12.5% EtOH v/v) from 4 days prior to mating until 4 days of gestation (n=12/group). A subset of offspring was fed a HFD between 3-8 months of age. In males, PC:EtOH and HFD increased total body fat mass (PPC:EtOH<0.05; PHFD<0.0001), whereas in females, only HFD increased fat mass (PHFD<0.0001). PC:EtOH increased microvesicular liver steatosis in male, but not female offspring. Plasma triglycerides, HDL and cholesterol were increased in PC:EtOH-exposed males (PPC:EtOH<0.05); and LDL, cholesterol and leptin in PC:EtOH-exposed females (PPC:EtOH<0.05). mRNA levels of Tnf-α and Lep in visceral adipose tissue were increased by PC:EtOH in both sexes (PPC:EtOH<0.05) and IL-6 mRNA was increased in males (PPC:EtOH<0.05). This was associated with reduced miR-26a expression, a known regulator of IL6 and TNFα. Alcohol exposure around conception increases obesity risk, alters plasma lipid and leptin profiles and induces liver steatosis in a sex-specific manner. These programmed phenotypes were similar to those caused by a postnatal HFD, particularly in male offspring. These results have implications for the health of offspring whose mothers consumed alcohol around the time of conception.

Publisher URL: http://doi.org/10.1152/ajpendo.00251.2017

DOI: 10.1152/ajpendo.00251.2017

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