Advanced Synthesis and Catalysis
Advanced Synthesis and Catalysis
5 years ago

Stereoselective Vicinal Difunctionalization of Alkynes through a Three-Component Reaction of Alkynes, Sodium Sulfinates, and Togni Reagent

Stereoselective Vicinal Difunctionalization of Alkynes through a Three-Component Reaction of Alkynes, Sodium Sulfinates, and Togni Reagent
Yuanchao Xiang, Yunyan Kuang, Yuewen Li, Jie Wu
Stereoselective vicinal difunctionalization of alkynes through trifluoromethylation and sulfonylation via a three-component reaction of alkynes, sodium sulfinates, and Togni reagent under catalyst- and additive-free conditions has been realized. This reaction proceeds at room temperature in dimethyl sulfoxide (DMSO), providing (E)-β-trifluoromethylvinyl sulfones in moderate to good yields. The advantages of this tandem radical process include extremely mild conditions, excellent stereoselectivity, and easy experimental operation.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adsc.201700278

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