Advanced Synthesis and Catalysis
Advanced Synthesis and Catalysis
5 years ago

Cp*Rh(III)-Catalyzed Directed C−H Methylation and Arylation of Quinoline N-Oxides at the C-8 Position

Cp*Rh(III)-Catalyzed Directed C−H Methylation and Arylation of Quinoline N-Oxides at the C-8 Position
Bao Wang, Hong Liu, Chunpu Li
Herein, we report a Cp*Rh(III)-catalyzed directed C−H methylation of quinoline N-oxides at the C-8 position using commercially available organotrifluoroborates as reagents. This method features perfect regioselectivity, relatively mild reaction conditions, and diverse functional group tolerance with good to excellent yields. Additionally, direct C-8 arylated quinoline N-oxides products could also be obtained under the same conditions. Preliminary mechanistic experiments were conducted and a possible mechanism was proposed.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adsc.201700484

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