Advanced Synthesis and Catalysis
Advanced Synthesis and Catalysis
5 years ago

Synergistic Strategies of Cyano Migration and Photocatalysis for Difunctionalization of Unactivated Alkenes: Synthesis of Di- and Mono-Fluorinated Alkyl Nitriles

Synergistic Strategies of Cyano Migration and Photocatalysis for Difunctionalization of Unactivated Alkenes: Synthesis of Di- and Mono-Fluorinated Alkyl Nitriles
Leitao Huan, Zhen Wu, Rongguo Ren, Chen Zhu
A general protocol for the challenging cyanofluoroalkylation of unactivated alkenes is disclosed. A broad range of synthetically useful di- and mono-fluorinated alkyl nitriles are readily obtained in good yields under mild reaction conditions. The efficient combination of intramolecular cyano migration and photoredox catalysis significantly expands the field of difunctionalization of olefins.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adsc.201700591

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